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PrP depletion in ATP7B-KO cells led to a decrease in Cu levels as shown using the fluorescent CF4 copper sensor and by ICP-OES (Fig

This provides the critical element for the phosphorylation of glucose, which participates in GSH regeneration via production of NADPH in the pentose phosphate pathway, improving the RBC antioxidant response against physiologic stimuli such as the transit into the sluggish splenic circulation

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